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e., Web) and serotonin (i.e, SERT). Mephedrone and methylone work as non-selective transporter substrates, thereby stimulating non-exocytotic release of dopamine, norepinephrine and serotonin. In contrast, MDPV acts for a strong blocker at DAT and NET, with tiny effect at SERT. Administration of mephedrone or methylone to rats will increase extrace